Lipid composition of viral envelope of three strains of influenza virus - not all viruses are created equal.

ABSTRACT: While differences in the rate of virus fusion and budding from the host cell membrane have been correlated with pathogenicity, no systematic study of the contribution of differences in viral envelope composition has previously been attempted. Using rigorous virus purification, marked differences between virions and host were observed. Over 125 phospholipid species have been quantitated for three strains of influenza (HKx31- H3N2, PR8- H1N1, and VN1203- H5N1) grown in eggs. The glycerophospholipid composition of purified virions differs from that of the host or that of typical mammalian cells. Phosphatidylcholine is the major component in most mammalian cell membranes, while in purified virions phosphatidylethanolamine dominates. Due to its effects on membrane curvature, it is likely that t

SUBMITTER: Ivanova PT 

PROVIDER: S-EPMC4593503 | biostudies-literature | 2015 Sep

REPOSITORIES: biostudies-literature