Are Structural Changes Induced by Lithium in the HIV Brain Accompanied by Changes in Functional Connectivity?

ABSTRACT: Lithium therapy has been shown to affect imaging measures of brain function and microstructure in human immunodeficiency virus (HIV)-infected subjects with cognitive impairment. The aim of this proof-of-concept study was to explore whether changes in brain microstructure also entail changes in functional connectivity. Functional MRI data of seven cognitively impaired HIV infected individuals enrolled in an open-label lithium study were included in the connectivity analysis. Seven regions of interest (ROI) were defined based on previously observed lithium induced microstructural changes measured by Diffusion Tensor Imaging. Generalized partial directed coherence (gPDC), based on time-variant multivariate autoregressive models, was used to quantify the degree of connectivity between the sele

SUBMITTER: Tivarus ME 

PROVIDER: S-EPMC4593570 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature