Engineering Proteins for Thermostability with iRDP Web Server.

ABSTRACT: Engineering protein molecules with desired structure and biological functions has been an elusive goal. Development of industrially viable proteins with improved properties such as stability, catalytic activity and altered specificity by modifying the structure of an existing protein has widely been targeted through rational protein engineering. Although a range of factors contributing to thermal stability have been identified and widely researched, the in silico implementation of these as strategies directed towards enhancement of protein stability has not yet been explored extensively. A wide range of structural analysis tools is currently available for in silico protein engineering. However these tools concentrate on only a limited number of factors or individual protein structures, res

SUBMITTER: Panigrahi P 

PROVIDER: S-EPMC4593602 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature