Resting-state functional connectivity in the baboon model of genetic generalized epilepsy.

ABSTRACT:

Objective

The baboon provides a natural model of genetic generalized epilepsy (GGE). This study compares the intrinsic connectivity networks of epileptic and healthy control baboons using resting-state functional magnetic resonance imaging (rs-fMRI) and data-driven functional connectivity mapping.

Methods

Twenty baboons, matched for gender, age, and weight, were classified into two groups (10 epileptic [EPI], 10 control [CTL]) on the basis of scalp electroencephalography (EEG) findings. Each animal underwent one MRI session that acquired one 5-min resting state fMRI scan and one anatomic MRI scan-used for registration and spatial normalization. Using independent component analysis, we identified 14 unique components/networks, which were then used to characterize each group's

SUBMITTER: Salinas FS 

PROVIDER: S-EPMC4593742 | biostudies-literature | 2015 Oct

REPOSITORIES: biostudies-literature