False-Positive Rate of AKI Using Consensus Creatinine-Based Criteria.

ABSTRACT:

Background and objectives

Use of small changes in serum creatinine to diagnose AKI allows for earlier detection but may increase diagnostic false-positive rates because of inherent laboratory and biologic variabilities of creatinine.

Design, setting, participants, & measurements

We examined serum creatinine measurement characteristics in a prospective observational clinical reference cohort of 2267 adult patients with AKI by Kidney Disease Improving Global Outcomes creatinine criteria and used these data to create a simulation cohort to model AKI false-positive rates. We simulated up to seven successive blood draws on an equal population of hypothetical patients with unchanging true serum creatinine values. Error terms generated from laboratory and biologic variabilities wer

SUBMITTER: Lin J 

PROVIDER: S-EPMC4594067 | biostudies-literature | 2015 Oct

REPOSITORIES: biostudies-literature