Aberrant intra- and inter-network connectivity architectures in Alzheimer's disease and mild cognitive impairment.

ABSTRACT: Alzheimer's disease (AD) patients and those with high-risk mild cognitive impairment are increasingly considered to have dysfunction syndromes. Large-scale network studies based on neuroimaging techniques may provide additional insight into AD pathophysiology. The aim of the present study is to evaluate the impaired network functional connectivity with the disease progression. For this purpose, we explored altered functional connectivities based on previously well-defined brain areas that comprise the five key functional systems [the default mode network (DMN), dorsal attention network (DAN), control network (CON), salience network (SAL), sensorimotor network (SMN)] in 35 with AD and 27 with mild cognitive impairment (MCI) subjects, compared with 27 normal cognitive subjects. Based on thre

SUBMITTER: Wang P 

PROVIDER: S-EPMC4594099 | biostudies-literature | 2015 Oct

REPOSITORIES: biostudies-literature