Treatment of Vitamin D Insufficiency in Postmenopausal Women: A Randomized Clinical Trial.

ABSTRACT:

Importance

Experts debate optimal 25-hydroxyvitamin D (25[OH]D) levels for musculoskeletal health.

Objective

To compare the effects of placebo, low-dose cholecalciferol, and high-dose cholecalciferol on 1-year changes in total fractional calcium absorption, bone mineral density, Timed Up and Go and five sit-to-stand tests, and muscle mass in postmenopausal women with vitamin D insufficiency.

Design, setting, and participants

This randomized, double-blind, placebo-controlled clinical trial was conducted at a single center in Madison, Wisconsin, from May 1, 2010, through July 31, 2013, and the final visit was completed on August 8, 2014. A total of 230 postmenopausal women 75 years or younger with baseline 25(OH)D levels of 14 through 27 ng/mL and no osteoporosis were s

SUBMITTER: Hansen KE 

PROVIDER: S-EPMC4594209 | biostudies-literature | 2015 Oct

REPOSITORIES: biostudies-literature