A Meta-analysis of the Association of Estimated GFR, Albuminuria, Diabetes Mellitus, and Hypertension With Acute Kidney Injury.

ABSTRACT:

Background

Diabetes mellitus and hypertension are risk factors for acute kidney injury (AKI). Whether estimated glomerular filtration rate (eGFR) and urine albumin-creatinine ratio (ACR) remain risk factors for AKI in the presence and absence of these conditions is uncertain.

Study design

Meta-analysis of cohort studies.

Setting & population

8 general-population (1,285,045 participants) and 5 chronic kidney disease (CKD; 79,519 participants) cohorts.

Selection criteria for studies

Cohorts participating in the CKD Prognosis Consortium.

Predictors

Diabetes and hypertension status, eGFR by the 2009 CKD Epidemiology Collaboration creatinine equation, urine ACR, and interactions.

Outcome

Hospitalization with AKI, using Cox proportional hazards models t

SUBMITTER: James MT 

PROVIDER: S-EPMC4594211 | biostudies-literature | 2015 Oct

REPOSITORIES: biostudies-literature