Ventromedial prefrontal cortex drives hippocampal theta oscillations induced by mismatch computations.

ABSTRACT: Detecting environmental change is fundamental for adaptive behavior in an uncertain world. Previous work indicates the hippocampus supports the generation of novelty signals via implementation of a match-mismatch detector that signals when an incoming sensory input violates expectations based on past experience. While existing work has emphasized the particular contribution of the hippocampus, here we ask which other brain structures also contribute to match-mismatch detection. Furthermore, we leverage the fine-grained temporal resolution of magnetoencephalography (MEG) to investigate whether mismatch computations are spectrally confined to the theta range, based on the prominence of this range of oscillations in models of hippocampal function. By recording MEG activity while human subject

SUBMITTER: Garrido MI 

PROVIDER: S-EPMC4594308 | biostudies-literature | 2015 Oct

REPOSITORIES: biostudies-literature