Relevance of the plasma membrane calcium-ATPase in the homeostasis of calcium in the fetal liver.

ABSTRACT: During the early stages of development, the embryo depends on the placenta as provider of oxygen and calcium, among other essential compounds. Although fetal liver accomplishes a well-known haematopoietic function, its contribution to calcium homeostasis upon development is poorly understood. The homeostasis of cell calcium contributes to diverse signaling pathways across developmental stages of most tissues and the calcium-ATPase located at the plasma membrane (PMCA) helps pumping excess calcium into the extracellular space. To date, the understanding of the equilibrium shift between PMCA isoforms during liver development is still missing. This review focuses on the characterization of the hepatic PMCA along the early stages of development, followed by a description of modern approaches t

SUBMITTER: Delgado-Coello B 

PROVIDER: S-EPMC4594366 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature