Mass spectrometry based analysis of human plasma-derived factor X revealed novel post-translational modifications.

ABSTRACT: Human coagulation factor X is a central component of the blood coagulation cascade that converts, under its activated form, prothrombin into thrombin. Generation of thrombin is the final step of the clotting cascade that leads to the clot by polymerization of fibrinogen molecules into a fibrin network. Today, research of new by-passing agents of the coagulation may contribute to an increased interest for human factor X, which may, in consequence, lead to the need of a more exhaustive picture of its structural features. Several post-translational modifications of human factor X such as γ-carboxylation/β-hydroxylation of the N-terminal light chain and N-/O-glycosylation of the activation peptide have been described. But, so far as we know, no comprehensive studies of its post-translational m

SUBMITTER: Chevreux G 

PROVIDER: S-EPMC4594663 | biostudies-literature | 2015 Oct

REPOSITORIES: biostudies-literature