Genotype-guided drug prescribing: a systematic review and meta-analysis of randomized control trials.

ABSTRACT:

Aim

Adverse drug events lead to increased morbidity, mortality and health care costs. Pharmacogenetic testing that guides drug prescribing has the potential to reduced adverse drug events and increase drug effectiveness. Our aim was to quantify the clinical effectiveness of genotype-guided prescribing.

Methods

Three electronic databases were searched from January 1980 through December 2013. Studies were eligible if they were RCTs comparing genotype-guided prescribing with non-genetic informed prescribing, reported drug specific adverse drug events and clinical effectiveness outcomes. Two reviewers independently screened titles and abstracts, extracted data and assessed study quality. Meta-analyses of specific outcomes were conducted where data allowed.

Results

Fifteen

SUBMITTER: Goulding R 

PROVIDER: S-EPMC4594730 | biostudies-literature | 2015 Oct

REPOSITORIES: biostudies-literature