Inflammatory spleen monocytes can upregulate CD11c expression without converting into dendritic cells.

ABSTRACT: Monocytes can differentiate into various cell types with unique specializations depending on their environment. Under certain inflammatory conditions, monocytes upregulate expression of the dendritic cell marker CD11c together with MHC and costimulatory molecules. These phenotypic changes indicate monocyte differentiation into a specialized subset of dendritic cells (DCs), often referred to as monocyte-derived DCs or inflammatory DCs (iDCs), considered important mediators of immune responses under inflammatory conditions triggered by infection or vaccination. To characterize the relative contribution of cDCs and iDCs under conditions that induce strong immunity to coadministered Ags, we analyzed the behavior of spleen monocytes in response to anti-CD40 treatment. We found that under steril

SUBMITTER: Drutman SB 

PROVIDER: S-EPMC4594880 | biostudies-literature | 2012 Apr

REPOSITORIES: biostudies-literature