The anti-aging properties of a human placental hydrolysate combined with dieckol isolated from Ecklonia cava.

ABSTRACT:

Backgrounds

In the present study, we aimed to examine the anti-aging properties of human placental hydrolysate (HPE) and dieckol (DE) from Ecklonia cava against free radical scavenging, muscle hypertrophy-related follistatin mRNA expression, amelioration of cognition-related genes and proteins, inhibition of collagenase-regulating genes, and elastinase activity.

Methods

The anti-aging effects were examined in human fibroblast (CCD986sk), mouse myoblast (C2C12), and neuroblastoma (N2a) cell models, by employing various assays such as 2,2-diphenyl-1-picrylhydrazyl hydrate (DPPH) scavenging, hydroxyl radical-mediated oxidation, quantitative real-time polymerase chain reaction, enzyme activity, and immunocytochemistry observation.

Results

Our results show that HPE combine

SUBMITTER: Jang SK 

PROVIDER: S-EPMC4594884 | biostudies-literature | 2015 Oct

REPOSITORIES: biostudies-literature