ABCB1 C3435T polymorphism and the lipid-lowering response in hypercholesterolemic patients on statins: a meta-analysis.

ABSTRACT:

Background

A number of researches have evaluated the association between the ABCB1 polymorphism and the lipid-lowering response of statins, but the results have been inconclusive. To examine the lipid-lowering efficacy and safety associated with the ABCB1 C3435T polymorphism in hypercholesterolemic patients receiving statin, all available studies were included in this meta-analysis.

Methods

A systematic search for eligible studies in the Cochrane library database, Scopus and PubMed was performed. Articles meeting the inclusion criteria were comprehensively reviewed, and the available data were accumulated by the meta-analysis.

Results

The results indicated that the comparisons of CC+CT vs. TT were associated with a significant elevation of the serum HDL-C levels after

SUBMITTER: Su J 

PROVIDER: S-EPMC4594898 | biostudies-literature | 2015 Oct

REPOSITORIES: biostudies-literature