Relationships between mitochondrial content and bioenergetics with obesity, body composition and fat distribution in healthy older adults.

ABSTRACT:

Background

Mitochondrial function declines with age; however, the relationship between adiposity and mitochondrial function among older adults is unclear. This study examined relationships between skeletal muscle mitochondrial content and electron transport chain complex 2 driven respiration with whole body and thigh composition, body fat distribution, and insulin sensitivity in older adults.

Methods

25 healthy, sedentary, weight-stable men (N = 13) and women (N = 12) >65 years of age, with a BMI range of 18-35 kg/m(2), participated in this study. Vastus lateralis biopsies were analyzed for citrate synthase (CS) activity and succinate mediated respiration of isolated mitochondria. Whole body and thigh composition were measured by DXA and CT. HOMA-IR was calculated using fast

SUBMITTER: Bharadwaj MS 

PROVIDER: S-EPMC4594906 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature