Cytokine inhibition in chronic fatigue syndrome patients: study protocol for a randomized controlled trial.

ABSTRACT:

Background

Chronic fatigue syndrome (CFS) is a medically unexplained syndrome for which no somatic or pharmacological treatment has been proven effective. Dysfunction of the cytokine network has been suspected to play a role in the pathophysiology of CFS. The disturbances of the cytokine network detected in CFS patients are highly variable, in part due to the lack of adequate controls in many studies. Furthermore, all studies have been performed on peripheral venous blood of patients. As cytokines mainly act in tissues, for example, the brain, the information that can be derived from peripheral blood cells is limited. The information regarding the possible role of cytokines in the pathophysiology could come from intervention studies in which the activities of relevant cytokines are

SUBMITTER: Roerink ME 

PROVIDER: S-EPMC4595002 | biostudies-literature | 2015 Oct

REPOSITORIES: biostudies-literature