Indomethacin induced gene regulation in the rat hippocampus.

ABSTRACT:

Background

Non-steroidal anti-inflammatory drugs such as indomethacin are widely used to treat inflammatory diseases and manage pain, fever and inflammation in several conditions, including neuropsychiatric disorders. Although they predominantly function by inhibiting cyclooxygenase (COX) activity, important COX-independent actions also occur. These actions could be responsible for the adverse side effects associated with chronic and/or high dose usage of this popular drug class.

Results

We examined gene regulation in the hippocampus after peripheral administration of indomethacin by employing a microarray approach. Secondary confirmation and the brain expression pattern of regulated genes was examined by in situ hybridization and immunohistochemistry. Transglutaminase 2, se

SUBMITTER: Sathyanesan M 

PROVIDER: S-EPMC4595115 | biostudies-literature | 2015 Oct

REPOSITORIES: biostudies-literature