The common NOD2/CARD15 variant P268S in patients with non-infectious uveitis: a cohort study.

ABSTRACT:

Background

The etiology of Autoimmune chronic uveitis (ACU) is still unknown; NOD2/CARD15 gene mutations are responsible for the Blau Syndrome and can induce uveitis in animal models.

Presentation of the hypothesis

Aim of our study was to assess if NOD2/CARD15 variants have a role in the etiology or in the clinical course of patients with ACU, either idiopathic or associated with other inflammatory diseases.

Testing the hypothesis

We consecutively enrolled 25 patients (19 pediatric and 6 adults) affected with ACU. For each patient medical history was reviewed and clinical data were recorded. Allelic and genotypic frequencies of NOD2/CARD15 variations were calculated in patients and matched with those of 25 healthy controls. The statistical analysis was performed. Fift

SUBMITTER: Marrani E 

PROVIDER: S-EPMC4595328 | biostudies-literature | 2015 Oct

REPOSITORIES: biostudies-literature