Association of WNT4 polymorphisms with endometriosis in infertile patients.

ABSTRACT:

Purpose

Recently, several genome-wide association studies have demonstrated an association between endometriosis and markers located in or near to WNT4 gene. In order to assess the validity of the findings, we conducted a replication case-control study in a Brazilian population.

Methods

Genetic association study comprising 400 infertile women with endometriosis and 400 fertile women as controls. TaqMan allelic discrimination technique was used to investigate the relationship between endometriosis and four single-nucleotide polymorphisms (rs16826658, rs3820282, rs2235529, and rs7521902) in WNT4 gene. Genotype distribution, allele frequency, and haplotype analysis of the WNT4 polymorphisms were performed. A p value <0.05 was considered significant.

Results

The results r

SUBMITTER: Mafra F 

PROVIDER: S-EPMC4595394 | biostudies-literature | 2015 Sep

REPOSITORIES: biostudies-literature