MDR1/ABCB1 gene polymorphisms in patients with chronic myeloid leukemia.

ABSTRACT:

Background

Tyrosine kinase inhibitors (TKIs) are the recommended treatment for patients with chronic myeloid leukemia (CML). The MDR1/ABCB1 gene plays a role in resistance to a wide spectrum of drugs, including TKIs. However, the association of MDR1/ABCB1 gene polymorphisms (SNPs) such as C1236T, G2677T/A, and C3435T with the clinical therapeutic evolution of CML has been poorly studied. We investigated these gene polymorphisms in CML-patients treated with imatinib, nilotinib and/or dasatinib.

Methods

ABCB1-SNPs were studied in 22 CML-patients in the chronic phase (CP) and 2 CML-patients in blast crisis (BC), all of whom were treated with TKIs, and compared with 25 healthy controls using nested-PCR and sequencing techniques.

Results

Seventeen different haplotypes were

SUBMITTER: Lardo M 

PROVIDER: S-EPMC4595581 | biostudies-literature | 2015 Sep

REPOSITORIES: biostudies-literature