Identification of Immune-Relevant Factors Conferring Sarcoidosis Genetic Risk.

ABSTRACT:

Rationale

Genetic variation plays a significant role in the etiology of sarcoidosis. However, only a small fraction of its heritability has been explained so far.

Objectives

To define further genetic risk loci for sarcoidosis, we used the Immunochip for a candidate gene association study of immune-associated loci.

Methods

Altogether the study population comprised over 19,000 individuals. In a two-stage design, 1,726 German sarcoidosis cases and 5,482 control subjects were genotyped for 128,705 single-nucleotide polymorphisms using the Illumina Immunochip for the screening step. The remaining 3,955 cases, 7,514 control subjects, and 684 parents of affected offspring were used for validation and replication of 44 candidate and two established risk single-nucleotide poly

SUBMITTER: Fischer A 

PROVIDER: S-EPMC4595678 | biostudies-literature | 2015 Sep

REPOSITORIES: biostudies-literature