A Genome-Wide Association Study of Emphysema and Airway Quantitative Imaging Phenotypes.

ABSTRACT:

Rationale

Chronic obstructive pulmonary disease (COPD) is defined by the presence of airflow limitation on spirometry, yet subjects with COPD can have marked differences in computed tomography imaging. These differences may be driven by genetic factors. We hypothesized that a genome-wide association study (GWAS) of quantitative imaging would identify loci not previously identified in analyses of COPD or spirometry. In addition, we sought to determine whether previously described genome-wide significant COPD and spirometric loci were associated with emphysema or airway phenotypes.

Objectives

To identify genetic determinants of quantitative imaging phenotypes.

Methods

We performed a GWAS on two quantitative emphysema and two quantitative airway imaging phenotypes in the

SUBMITTER: Cho MH 

PROVIDER: S-EPMC4595690 | biostudies-literature | 2015 Sep

REPOSITORIES: biostudies-literature