A FAST ALGORITHM FOR DETECTING GENE-GENE INTERACTIONS IN GENOME-WIDE ASSOCIATION STUDIES.

ABSTRACT: With the recent advent of high-throughput genotyping techniques, genetic data for genome-wide association studies (GWAS) have become increasingly available, which entails the development of efficient and effective statistical approaches. Although many such approaches have been developed and used to identify single-nucleotide polymorphisms (SNPs) that are associated with complex traits or diseases, few are able to detect gene-gene interactions among different SNPs. Genetic interactions, also known as epistasis, have been recognized to play a pivotal role in contributing to the genetic variation of phenotypic traits. However, because of an extremely large number of SNP-SNP combinations in GWAS, the model dimensionality can quickly become so overwhelming that no prevailing variable selection

SUBMITTER: Li J 

PROVIDER: S-EPMC4595934 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature