α-Klotho Expression in Human Tissues.

ABSTRACT:

Context

α-Klotho has emerged as a powerful regulator of the aging process. To date, the expression profile of α-Klotho in human tissues is unknown, and its existence in some human tissue types is subject to much controversy.

Objective

This is the first study to characterize systemwide tissue expression of transmembrane α-Klotho in humans. We have employed next-generation targeted proteomic analysis using parallel reaction monitoring in parallel with conventional antibody-based methods to determine the expression and spatial distribution of human α-Klotho expression in health.

Results

The distribution of α-Klotho in human tissues from various organ systems, including arterial, epithelial, endocrine, reproductive, and neuronal tissues, was first identified by immunohist

SUBMITTER: Lim K 

PROVIDER: S-EPMC4596032 | biostudies-literature | 2015 Oct

REPOSITORIES: biostudies-literature