Steroid Sex Hormones, Sex Hormone-Binding Globulin, and Diabetes Incidence in the Diabetes Prevention Program.

ABSTRACT:

Context

Steroid sex hormones and SHBG may modify metabolism and diabetes risk, with implications for sex-specific diabetes risk and effects of prevention interventions.

Objective

This study aimed to evaluate the relationships of steroid sex hormones, SHBG and SHBG single-nucleotide polymorphisms (SNPs) with diabetes risk factors and with progression to diabetes in the Diabetes Prevention Program (DPP).

Design and setting

This was a secondary analysis of a multicenter randomized clinical trial involving 27 U.S. academic institutions.

Participants

The study included 2898 DPP participants: 969 men, 948 premenopausal women not taking exogenous sex hormones, 550 postmenopausal women not taking exogenous sex hormones, and 431 postmenopausal women taking exogenous sex

SUBMITTER: Mather KJ 

PROVIDER: S-EPMC4596040 | biostudies-literature | 2015 Oct

REPOSITORIES: biostudies-literature