Adjustment of Open-Loop Settings to Improve Closed-Loop Results in Type 1 Diabetes: A Multicenter Randomized Trial.

ABSTRACT:

Context

Closed-loop control (CLC) relies on an individual's open-loop insulin pump settings to initialize the system. Optimizing open-loop settings before using CLC usually requires significant time and effort.

Objective

The objective was to investigate the effects of a one-time algorithmic adjustment of basal rate and insulin to carbohydrate ratio open-loop settings on the performance of CLC.

Design

This study reports a multicenter, outpatient, randomized, crossover clinical trial.

Patients

Thirty-seven adults with type 1 diabetes were enrolled at three clinical sites.

Interventions

Each subject's insulin pump settings were subject to a one-time algorithmic adjustment based on 1 week of open-loop (i.e., home care) data collection. Subjects then underwen

SUBMITTER: Dassau E 

PROVIDER: S-EPMC4596045 | biostudies-literature | 2015 Oct

REPOSITORIES: biostudies-literature