Susceptibility Genes for Multiple Sclerosis Identified in a Gene-Based Genome-Wide Association Study.

ABSTRACT:

Background and purpose

Multiple sclerosis (MS) is a demyelinating and inflammatory disease of the central nervous system. The aim of this study was to identify more genes associated with MS.

Methods

Based on the publicly available data of the single-nucleotide polymorphism-based genome-wide association study (GWAS) from the database of Genotypes and Phenotypes, we conducted a powerful gene-based GWAS in an initial sample with 931 family trios, and a replication study sample with 978 cases and 883 controls. For interesting genes, gene expression in MS-related cells between MS cases and controls was examined by using publicly available datasets.

Results

A total of 58 genes was identified, including 20 "novel" genes significantly associated with MS (p<1.40×10⁻⁴). In the

SUBMITTER: Lin X 

PROVIDER: S-EPMC4596110 | biostudies-literature | 2015 Oct

REPOSITORIES: biostudies-literature