Identification of Serum Markers of Esophageal Adenocarcinoma by Global and Targeted Metabolic Profiling.

ABSTRACT:

Background & aims

We aimed to identify new serum biomarkers of esophageal adenocarcinoma (EAC).

Methods

We performed metabolomic analyses of serum samples from 2 sets of case-control pairs in the discovery phase, each consisting of 30 patients with histologically confirmed EAC (cases) from the University of Texas MD Anderson Cancer Center and 30 matched subjects without EAC (controls). We identified metabolites whose levels differed significantly between cases and controls and validated those with the greatest difference in an analysis of 321 EAC cases and 331 controls. We generated a metabolite risk score (MRS) for the metabolites.

Results

The levels of 64 metabolites differed significantly between EAC cases and controls in the discovery phase. The metabolites with t

SUBMITTER: Sanchez-Espiridion B 

PROVIDER: S-EPMC4596233 | biostudies-literature | 2015 Oct

REPOSITORIES: biostudies-literature