Molecular network of important genes for systemic sclerosis-related progressive lung fibrosis.

ABSTRACT:

Background

Considerable progress has been made in illuminating the pathological events for systemic sclerosis (SSc)-related progressive lung fibrosis. The molecular events that lead to SSc-related progressive lung fibrosis need to be defined. Some important genes have been identified from a recent study in humans. We aim to construct and compare the similarities and differences of molecular pathways between SSc-related progressive lung fibrosis and normal lungs of humans and mice.

Methods

We used the analytical approach of association of key genes in SSc-related progressive lung fibrosis. We first identified the probes for genes of SSc-related progressive lung fibrosis and analyzed the pathways in human lung using data generated by microarray. We then analyzed the gene pathw

SUBMITTER: Jiao Y 

PROVIDER: S-EPMC4596290 | biostudies-literature | 2015 Oct

REPOSITORIES: biostudies-literature