Association between the APOB XbaI and EcoRI polymorphisms and lipids in Chinese: a meta-analysis.

ABSTRACT:

Background

No previous meta-analysis was to report the association between the apolipoprotein B (APOB) XbaI and EcoRI polymorphisms and serum lipids in Chinese. We performed the study to investigate their potentially association.

Methods and results

Studies in English and Chinese were found via a systematic search of Pubmed, Embase, CNKI and Wanfang databases. The dominant genetic model and random-effects model were used to pool data from individual studies. As a result, a total of 30 articles with 5611 subjects for XbaI and 2653 subjects for EcoRI were included in the current study. For the XbaI polymorphism, overall, subjects carrying X+ allele were significantly associated with higher TC,TG and LDL compared with X-X- genotype (Pvalue = 0.0006, OR (95 %) = -0.55 (-0.86,-0.

SUBMITTER: Gu W 

PROVIDER: S-EPMC4596460 | biostudies-literature | 2015 Oct

REPOSITORIES: biostudies-literature