Sequence of Molecular Events during the Maturation of the Developing Mouse Prefrontal Cortex.

ABSTRACT: Recent progress in psychiatric research has accumulated many mouse models relevant to developmental neuropsychiatric disorders using numerous genetic and environmental manipulations. Since the prefrontal cortex (PFC) is essential for cognitive functions whose impairments are central symptoms associated with the disorders in humans, it has become crucial to clarify altered developmental processes of PFC circuits in these mice. To that end, we aimed to understand a sequence of molecular events during normal mouse PFC development. Expression profiles for representative genes covering diverse biological processes showed that while there were little changes in genes for neuroreceptors and synaptic molecules during postnatal period, there were dramatic increases in expression of myelin-related g

SUBMITTER: Ueda S 

PROVIDER: S-EPMC4596535 | biostudies-literature | 2015 Jul

REPOSITORIES: biostudies-literature