Modulation of Dendritic Cell Activation and Subsequent Th1 Cell Polarization by Lidocaine.

ABSTRACT: Dendritic cells play an essential role in bridging innate and adaptive immunity by recognizing cellular stress including pathogen- and damage-associated molecular patterns and by shaping the types of antigen-specific T cell immunity. Although lidocaine is widely used in clinical settings that trigger cellular stress, it remains unclear whether such treatment impacts the activation of innate immune cells and subsequent differentiation of T cells. Here we showed that lidocaine inhibited the production of IL-6, TNFα and IL-12 from dendritic cells in response to toll-like receptor ligands including lipopolysaccharide, poly(I:C) and R837 in a dose-dependent manner. Notably, the differentiation of Th1 cells was significantly suppressed by the addition of lidocaine while the same treatment had li

SUBMITTER: Jeon YT 

PROVIDER: S-EPMC4596553 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature