Conservation of Regional Variation in Sex-Specific Sex Chromosome Regulation.

ABSTRACT: Regional variation in sex-specific gene regulation has been observed across sex chromosomes in a range of animals and is often a function of sex chromosome age. The avian Z chromosome exhibits substantial regional variation in sex-specific regulation, where older regions show elevated levels of male-biased expression. Distinct sex-specific regulation also has been observed across the male hypermethylated (MHM) region, which has been suggested to be a region of nascent dosage compensation. Intriguingly, MHM region regulatory features have not been observed in distantly related avian species despite the hypothesis that it is situated within the oldest region of the avian Z chromosome and is therefore orthologous across most birds. This situation contrasts with the conservation of other aspec

SUBMITTER: Wright AE 

PROVIDER: S-EPMC4596671 | biostudies-literature | 2015 Oct

REPOSITORIES: biostudies-literature