Regulatory Rewiring in a Cross Causes Extensive Genetic Heterogeneity.

ABSTRACT: Genetic heterogeneity occurs when individuals express similar phenotypes as a result of different underlying mechanisms. Although such heterogeneity is known to be a potential source of unexplained heritability in genetic mapping studies, its prevalence and molecular basis are not fully understood. Here we show that substantial genetic heterogeneity underlies a model phenotype--the ability to grow invasively--in a cross of two Saccharomyces cerevisiae strains. The heterogeneous basis of this trait across genotypes and environments makes it difficult to detect causal loci with standard genetic mapping techniques. However, using selective genotyping in the original cross, as well as in targeted backcrosses, we detected four loci that contribute to differences in the ability to grow invasivel

SUBMITTER: Matsui T 

PROVIDER: S-EPMC4596683 | biostudies-literature | 2015 Oct

REPOSITORIES: biostudies-literature