Protein disulfide isomerase-endoplasmic reticulum resident protein 57 regulates allergen-induced airways inflammation, fibrosis, and hyperresponsiveness.

ABSTRACT:

Background

Evidence for association between asthma and the unfolded protein response is emerging. Endoplasmic reticulum resident protein 57 (ERp57) is an endoplasmic reticulum-localized redox chaperone involved in folding and secretion of glycoproteins. We have previously demonstrated that ERp57 is upregulated in allergen-challenged human and murine lung epithelial cells. However, the role of ERp57 in asthma pathophysiology is unknown.

Objectives

Here we sought to examine the contribution of airway epithelium-specific ERp57 in the pathogenesis of allergic asthma.

Methods

We examined the expression of ERp57 in human asthmatic airway epithelium and used murine models of allergic asthma to evaluate the relevance of epithelium-specific ERp57.

Results

Lung biopsy sp

SUBMITTER: Hoffman SM 

PROVIDER: S-EPMC4597791 | biostudies-literature | 2016 Mar

REPOSITORIES: biostudies-literature