Towards a Hierarchical Strategy to Explore Multi-Scale IP/MS Data for Protein Complexes.

ABSTRACT: Protein interaction in cells can be described at different levels. At a low interaction level, proteins function together in small, stable complexes and at a higher level, in sets of interacting complexes. All interaction levels are crucial for the living organism, and one of the challenges in proteomics is to measure the proteins at their different interaction levels. One common method for such measurements is immunoprecipitation followed by mass spectrometry (IP/MS), which has the potential to probe the different protein interaction forms. However, IP/MS data are complex because proteins, in their diverse interaction forms, manifest themselves in different ways in the data. Numerous bioinformatic tools for finding protein complexes in IP/MS data are currently available, but most tools do

SUBMITTER: Kutzera J 

PROVIDER: S-EPMC4598013 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature