Reliability of Two Diameters Method in Determining Acute Infarct Size. Validation as New Imaging Biomarker.

ABSTRACT:

Background

In order to select patients most likely to benefit for thrombolysis and to predict patient outcome in acute ischemic stroke, the volumetric assessment of the infarcted tissue is used. However, infarct volume estimation on Diffusion weighted imaging (DWI) has moderate interrater variability despite the excellent contrast between ischemic lesion and healthy tissue. In this study, we compared volumetric measurements of DWI hyperintensity to a simple maximum orthogonal diameter approach to identify thresholds indicating infarct size >70 ml and >100 ml.

Methods

Patients presenting with ischemic stroke with an NIHSS of ≥ 8 were examined with stroke MRI within 24 h after symptom onset. For assessment of the orthogonal DWI lesion diameters (od-values) the image with the l

SUBMITTER: Fiebach JB 

PROVIDER: S-EPMC4598169 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature