Optical Verification of Microbubble Response to Acoustic Radiation Force in Large Vessels With In Vivo Results.

ABSTRACT:

Objective

The objective of this study was to optically verify the dynamic behaviors of adherent microbubbles in large blood vessel environments in response to a new ultrasound technique using modulated acoustic radiation force.

Materials and methods

Polydimethylsiloxane (PDMS) flow channels coated with streptavidin were used in targeted groups to mimic large blood vessels. The custom-modulated acoustic radiation force beam sequence was programmed on a Verasonics research scanner. In vitro experiments were performed by injecting a biotinylated lipid-perfluorobutane microbubble dispersion through flow channels. The dynamic response of adherent microbubbles was detected acoustically and simultaneously visualized using a video camera connected to a microscope. In vivo verificati

SUBMITTER: Wang S 

PROVIDER: S-EPMC4598275 | biostudies-literature | 2015 Nov

REPOSITORIES: biostudies-literature