Computational implementation of a tunable multicellular memory circuit for engineered eukaryotic consortia.

ABSTRACT: Cells are complex machines capable of processing information by means of an entangled network of molecular interactions. A crucial component of these decision-making systems is the presence of memory and this is also a specially relevant target of engineered synthetic systems. A classic example of memory devices is a 1-bit memory element known as the flip-flop. Such system can be in principle designed using a single-cell implementation, but a direct mapping between standard circuit design and a living circuit can be cumbersome. Here we present a novel computational implementation of a 1-bit memory device using a reliable multicellular design able to behave as a set-reset flip-flop that could be implemented in yeast cells. The dynamics of the proposed synthetic circuit is investigated with

SUBMITTER: Sardanyes J 

PROVIDER: S-EPMC4598587 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature