Attention to Automatic Movements in Parkinson's Disease: Modified Automatic Mode in the Striatum.

ABSTRACT: We investigated neural correlates when attending to a movement that could be made automatically in healthy subjects and Parkinson's disease (PD) patients. Subjects practiced a visuomotor association task until they could perform it automatically, and then directed their attention back to the automated task. Functional MRI was obtained during the early-learning, automatic stage, and when re-attending. In controls, attention to automatic movement induced more activation in the dorsolateral prefrontal cortex (DLPFC), anterior cingulate cortex, and rostral supplementary motor area. The motor cortex received more influence from the cortical motor association regions. In contrast, the pattern of the activity and connectivity of the striatum remained at the level of the automatic stage. In PD pat

SUBMITTER: Wu T 

PROVIDER: S-EPMC4598818 | biostudies-literature | 2015 Oct

REPOSITORIES: biostudies-literature