Fully automatic and robust 3D registration of serial-section microscopic images.

ABSTRACT: Robust and fully automatic 3D registration of serial-section microscopic images is critical for detailed anatomical reconstruction of large biological specimens, such as reconstructions of dense neuronal tissues or 3D histology reconstruction to gain new structural insights. However, robust and fully automatic 3D image registration for biological data is difficult due to complex deformations, unbalanced staining and variations on data appearance. This study presents a fully automatic and robust 3D registration technique for microscopic image reconstruction, and we demonstrate our method on two ssTEM datasets of drosophila brain neural tissues, serial confocal laser scanning microscopic images of a drosophila brain, serial histopathological images of renal cortical tissues and a synthetic t

SUBMITTER: Wang CW 

PROVIDER: S-EPMC4598826 | biostudies-literature | 2015 Oct

REPOSITORIES: biostudies-literature