Divergent DNA methylation patterns associated with gene expression in rice cultivars with contrasting drought and salinity stress response.

ABSTRACT: DNA methylation is an epigenetic mechanism that play an important role in gene regulation in response to environmental conditions. The understanding of DNA methylation at the whole genome level can provide insights into the regulatory mechanisms underlying abiotic stress response/adaptation. We report DNA methylation patterns and their influence on transcription in three rice (Oryza sativa) cultivars (IR64, stress-sensitive; Nagina 22, drought-tolerant; Pokkali, salinity-tolerant) via an integrated analysis of whole genome bisulphite sequencing and RNA sequencing. We discovered extensive DNA methylation at single-base resolution in rice cultivars, identified the sequence context and extent of methylation at each site. Overall, methylation levels were significantly different in the three ri

SUBMITTER: Garg R 

PROVIDER: S-EPMC4598828 | biostudies-literature | 2015 Oct

REPOSITORIES: biostudies-literature