Goodness-of-fit test of the stratified mark-specific proportional hazards model with continuous mark.

ABSTRACT: Motivated by the need to assess HIV vaccine efficacy, previous studies proposed an extension of the discrete competing risks proportional hazards model, in which the cause of failure is replaced by a continuous mark only observed at the failure time. However the model assumptions may fail in several ways, and no diagnostic testing procedure for this situation has been proposed. A goodness-of-fit test procedure for the stratified mark-specific proportional hazards model in which the regression parameters depend nonparametrically on the mark and the baseline hazards depends nonparametrically on both time and the mark is proposed. The test statistics are constructed based on the weighted cumulative mark-specific martingale residuals. The critical values of the proposed test statistics are app

SUBMITTER: Sun Y 

PROVIDER: S-EPMC4598956 | biostudies-literature | 2016 Jan

REPOSITORIES: biostudies-literature