Impact of preoperative serum albumin on 30-day mortality following surgery for colorectal cancer: a population-based cohort study.

ABSTRACT:

Objective

Surgery is the only potentially curable treatment for colorectal cancer (CRC), but it is hampered by high mortality. Human serum albumin (HSA) below 35 g/L is associated with poor overall prognosis in patients with CRC, but evidence regarding the impact on postoperative mortality is sparse.

Methods

We performed a population-based cohort study including patients undergoing CRC surgery in North and Central Denmark (1997-2011). We categorised patients according to HSA concentration measured 1-30 days prior to surgery date. We used the Kaplan-Meier method to compute 30-day mortality and Cox regression model to compute HRs as measures of the relative risk of death, controlling for potential confounders. We further stratified patients by preoperative conditions, includin

SUBMITTER: Montomoli J 

PROVIDER: S-EPMC4599163 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature