Reduced keratin expression in colorectal neoplasia and associated fields is reversible by diet and resection.

ABSTRACT:

Background

Patients with adenomatous colonic polyps are at increased risk of developing further polyps suggesting field-wide alterations in cancer predisposition. The current study aimed to identify molecular alterations in the normal mucosa in the proximity of adenomatous polyps and to assess the modulating effect of butyrate, a chemopreventive compound produced by fermentation of dietary residues.

Methods

A cross-sectional study was undertaken in patients with adenomatous polyps: biopsy samples were taken from the adenoma, and from macroscopically normal mucosa on the contralateral wall to the adenoma and from the mid-sigmoid colon. In normal subjects biopsies were taken from the mid-sigmoid colon. Biopsies were frozen for proteomic analysis or formalin-fixed for immunohis

SUBMITTER: Evans CA 

PROVIDER: S-EPMC4599164 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature