A meta-analysis of lipid peroxidation markers in major depression.

ABSTRACT: BACKGROUND:Major depressive disorder (MDD) may be associated with oxidative damage to lipids, which can potentially affect mood-regulating pathways. This meta-analysis summarizes current knowledge regarding lipid peroxidation markers in clinical samples of MDD and the effects of antidepressant pharmacotherapy on those markers. METHODS:MEDLINE, EMBASE, CINAHL, PsycINFO, and Cochrane Collaboration were searched for original, peer-reviewed articles measuring markers of lipid peroxidation in patients with MDD and nondepressed healthy controls up to April 2015. Standardized mean differences (SMDs) were generated from random effects models summarizing mean (± standard deviations) concentrations of selected markers. RESULTS:Lipid peroxidation was greater in MDD than in controls (studies =17, N=85

SUBMITTER: Mazereeuw G 

PROVIDER: S-EPMC4599178 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature