TRIM21, a negative modulator of LFG in breast carcinoma MDA-MB-231 cells in vitro.

ABSTRACT: Lifeguard (LFG) is a transmembrane protein which is highly expressed in tissues of the hippocampus and the cerebellum, especially during postnatal development. This protein is responsible for the protection of neurons against Fas-induced apoptosis, and the same effect can be seen in tumor cells derived from mastocarcinoma. However, the molecular function of LFG and its regulation in the carcinogenesis of human breast cells remains to be elucidated. In the present study, we investigated the connection of the interaction of LFG within an array analysis of over 9,000 different proteins. Results showed an interaction between the proteins tripartite motif-containing 21 (TRIM21) and LFG and a negative regulatory effect of TRIM21 towards LFG on the protein level. Furthermore, Fas-induced apoptosi

SUBMITTER: Muller J 

PROVIDER: S-EPMC4599183 | biostudies-literature | 2015 Nov

REPOSITORIES: biostudies-literature