Stromal androgen receptor regulates the composition of the microenvironment to influence prostate cancer outcome.

ABSTRACT: Androgen receptor (AR) signaling in stromal cells is important in prostate cancer, yet the mechanisms underpinning stromal AR contribution to disease development and progression remain unclear. Using patient-matched benign and malignant prostate samples, we show a significant association between low AR levels in cancer associated stroma and increased prostate cancer-related death at one, three and five years post-diganosis, and in tissue recombination models with primary prostate cancer cells that low stromal AR decreases castration-induced apoptosis. AR-regulation was found to be different in primary human fibroblasts isolated from adjacent to cancerous and non-cancerous prostate epithelia, and to represent altered activation of myofibroblast pathways involved in cell cycle, adhesion, mig

SUBMITTER: Leach DA 

PROVIDER: S-EPMC4599261 | biostudies-literature | 2015 Jun

REPOSITORIES: biostudies-literature