Smart hydrogels containing adenylate kinase: translating substrate recognition into macroscopic motion.

ABSTRACT: Enzyme-based hybrid hydrogels were prepared by covalently incorporating an adenylate kinase mutant, possessing two thiol groups, into HPMA copolymer- or PEG-based hydrogel structures. The nanoscale conformational change of enzyme, triggered by substrate recognition, translated into macroscopic motion of hydrogels.

SUBMITTER: Yuan W 

PROVIDER: S-EPMC4599350 | biostudies-literature | 2008 Nov

REPOSITORIES: biostudies-literature